Until now the therapeutic benefits of marijuana / Cannabis are still a major controversy, not only for Parkinson’s but also for many other diseases (epilepsy, multiple sclerosis, anxiety disorders, etc.). At present, drugs containing synthetic Cannabis or full spectrum – which are already recognized by the FDA are only Nabilone (a drug to reduce the effects of nausea and vomiting in post-chemotherapy) and Dronabinol (a drug to increase appetite in AIDS patients with anorexia). There are a number of things that I feel are the causes of the difficulty of claiming Cannabis can be one of Parkinson’s therapies; Until now we only know that the cause of Parkinson’s is the loss of the function of the substantia nigra in the basal ganglia producing dopamine. Dopamine functions to regulate human muscle movements. With reduced dopamine, symptoms of tremor, muscle stiffness, impaired balance and coordination, difficulty in facial expression, speech difficulties, etc. Are you considering full spectrum – no thc?
There are hundreds of chemical components in Cannabis plants which are about 100 of them are Cannabinoid groups. Of all these Cannabinoids there are 2 that are considered most important in the therapeutic effects of Tetrahydrocannabinol (THC) and Cannabidiol (CBD). The difference is, THC has psychoactive properties, meaning it can make people feel “high”. The mechanism of action is still unknown, the claims are anti-pain, anti-inflammatory, anti-cancer, anti-nausea, anti-anxiety, etc. The most studied mechanism of the two components is that they bind to one of the receptors in the brain whose function is to increase dopamine production so that it can help patients with dopamine deficiency. Unfortunately, when the research was conducted on humans, the data was not strong enough.
Beyond that there is still much other ballast that make research on the medical effects of Cannabis slow, for example there are still many areas that prohibit Cannabis circulation, still high public skepticism about the ill effects of Cannabis, difficulty getting a uniform Cannabis supply, difficulty determining the right dosage for effects maximal therapeutic with minimal psychoactive effects, etc.